![]() Image adapted from DataBase Center for Life Science (DBCLS), 201705 Scientist bench F. ![]() Open notebooks drastically reduce the time frame from bench to publication in the public domain. My specific aim was to create an open and collaborative network of researchers focused on answering some of the critical questions of HD protein biochemistry and reduce unnecessary duplication of effort.įig 1. I hoped that by documenting my research project through an open notebook and sharing data ahead of traditional publication timelines, I would speed up the research process for HD ( Fig 1). Open science and open notebooks promise to accelerate the process of scientific discovery. Although scientists mapped the causative mutation 25 years ago, successful development of disease-modifying or curative therapeutics has not materialized as hoped. My particular research focus is Huntington disease (HD), a devastating inherited neurodegenerative disease. Piloting innovative open science strategies is well supported and is encouraged for scientists working within the SGC. SGC scientists not only make their work as open as possible through extensive data and material sharing but have also recently implemented an open publication strategy, in which all manuscripts are submitted systematically to open access preprint servers. I am a postdoctoral fellow at the Structural Genomics Consortium (SGC), where open science is a critical part of the laboratory ethos. Starting my own open notebook for my postdoctoral research project was appealing for a number of reasons. Of those who have, many quickly abandon the practice or fail to update their notebook regularly or share it with restrictions. Despite the benefits of openly documenting research projects in real time, scientists have been slow to adopt open notebook science. In defining the practice, Bradley said, “It is essential that all of the information available to the researchers to make their conclusions is equally available to the rest of the world”, meaning that the notebook must be a complete and honest representation of the scientist’s findings. The term “open notebook science” was first coined in 2006 by Professor Jean-Claude Bradley, a Canadian chemistry researcher at Drexel University. Provenance: Commissioned not externally peer reviewed. Huntington’s Disease Society of America SGC, ![]() The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The author has declared that there are no competing interests.Ĭentral Oxford Structural Molecular Imaging Centre DOI, The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute, Innovative Medicines Initiative (EU/EFPIA), Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome. Harding is the recipient of the Huntington’s Disease Society of America Berman Topper Career Development Fellowship which funds and supports HD research in addition to generous funding from the Huntington Society of Canada and the CHDI Foundation. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: Dr. Citation: Harding RJ (2019) Open notebook science can maximize impact for rare disease projects. ![]()
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